The PIDDosome: centrosome guardian and backup on the DNA damage response

Matteo Burigotto; Luca L Fava

doi:10.1080/23723556.2021.1893625

The PIDDosome: centrosome guardian and backup on the DNA damage response

Mol Cell Oncol. 2021 Mar 28;8(3):1893625. doi: 10.1080/23723556.2021.1893625. eCollection 2021.

Authors

Matteo Burigotto¹, Luca L Fava¹

Affiliation

¹ Armenise-Harvard Laboratory of Cell Division, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy.

Abstract

The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of PIDD1 (p53-inducible protein with death domain) at the centrosome, demonstrating how this organelle can directly influence cell fate.

Keywords: DNA damage; PIDDosome; centrosome; p53.

Grants and funding

This work was supported by the Giovanni Armenise-Harvard Foundation [CDA 2017] and the University of Trento.