Stability data of extemporaneous suspensions of hydroxychloroquine sulphate in oral liquid bases after tablet manipulation

Mara Perrone; Valentino Laquintana; Angela Assunta Lopedota; Annalisa Cutrignelli; Antonio Lopalco; Massimo Franco; Antonio Pepe; Sergio Fontana; Nunzio Denora

doi:10.1016/j.dib.2020.106575

Stability data of extemporaneous suspensions of hydroxychloroquine sulphate in oral liquid bases after tablet manipulation

Data Brief. 2020 Nov 30:33:106575. doi: 10.1016/j.dib.2020.106575. eCollection 2020 Dec.

Authors

Mara Perrone¹, Valentino Laquintana², Angela Assunta Lopedota², Annalisa Cutrignelli², Antonio Lopalco², Massimo Franco², Antonio Pepe¹, Sergio Fontana¹, Nunzio Denora²

Affiliations

¹ Centro Studi e Ricerche "Dr. S. Fontana 1900-1982", Farmalabor s.r.l., Via Piano S. Giovanni, 47, 76012 Canosa di Puglia (BT), Italy.
² Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, 70125 Bari, Italy.

Abstract

Hydroxychloroquine is a well-known anti-malarial and anti-rheumatic drug that has garnered recently unprecedented attention as potential therapeutic agent against virus infections. Hydroxychloroquine sulphate is authorized in the EU as film-coated tablets (i.e. Plaquenil®), which cannot be administered to non-cooperative patients, such as those in intensive care units or, more in general, unable to swallow solid dosage forms. Therefore, the hospital pharmacist must manipulate the solid dosage form for the preparation of suspension, even if it can strongly affect the product quality. In this scenario, it is crucial to offer useful information and advice to assist hospital pharmacists in their activity. The data presented in this article suggest that extemporaneous suspensions of hydroxychloroquine sulphate in oral liquid bases after tablet manipulation are stable for at least 30 days.

Keywords: Extemporaneous suspension; Galenic formulation; Hydroxychloroquine sulphate; Liquid formulation; Oral liquid bases; Plaquenil; Turbiscan lab expert.