The Role of Ferroptosis in Acute Respiratory Distress Syndrome

Mengdi Qu; Hao Zhang; Zhaoyuan Chen; Xingfeng Sun; Shuainan Zhu; Ke Nan; Wankun Chen; Changhong Miao

doi:10.3389/fmed.2021.651552

The Role of Ferroptosis in Acute Respiratory Distress Syndrome

Front Med (Lausanne). 2021 May 7:8:651552. doi: 10.3389/fmed.2021.651552. eCollection 2021.

Authors

Mengdi Qu¹, Hao Zhang¹, Zhaoyuan Chen¹, Xingfeng Sun¹, Shuainan Zhu¹, Ke Nan¹, Wankun Chen¹, Changhong Miao¹

Affiliation

¹ Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Abstract

Ferroptosis is a newly discovered type of regulated cell death that is different from apoptosis, necrosis and autophagy. Ferroptosis is characterized by iron-dependent lipid peroxidation, which induces cell death. Iron, lipid and amino acid metabolism is associated with ferroptosis. Ferroptosis is involved in the pathological development of various diseases, such as neurological diseases and cancer. Recent studies have shown that ferroptosis is also closely related to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS), suggesting that it can be a novel therapeutic target. This article mainly introduces the metabolic mechanism related to ferroptosis and discusses its role in ALI/ARDS to provide new ideas for the treatment of these diseases.

Keywords: acute respiratory distress syndrome; ferroptosis; inflammation; metabolism; oxidative stress.

Publication types

Review