A Randomized Trial of Home Blood-Pressure Reduction by Alcohol Guidance During Outpatient Visits: OSAKE Study

Am J Hypertens. 2021 Oct 27;34(10):1108-1115. doi: 10.1093/ajh/hpab082.

Abstract

Background: To evaluate the effectiveness of the nurse-led alcohol guidance to control home blood pressure (HBP) in the morning among male patients with hypertension during outpatient visits.

Methods: We enrolled 53 male patients with an HBP of ≥135/85 mm Hg with excessive drinking (alcohol ≥210 g/week or ≥60 g/day habitually) among outpatients in a randomized trial. Patients were assigned to a nurse-led alcohol guidance intervention or to the control. The primary outcomes were the mean HBP of 5 consecutive days at 6 months and alcohol consumption.

Results: Twenty-eight and 25 patients were randomized to intervention and control groups, respectively (mean age; 62.7 years old and 64.5, respectively). At baseline, the groups were well balanced across most characteristics. At 6 months, the mean HBP was 131/82 mm Hg in the intervention group vs. 145/87 mm Hg in the control group (SBP <0.001, DBP = 0.09). An HBP level of less than 135/85 mm Hg was achieved among 55.6% of the participants in the intervention group vs. 16.7% in the control group (P = 0.004). The alcohol consumption at 6 months was 256 ± 206 g/w vs. 413 ± 260 g/w, respectively (P = 0.020).

Conclusions: We confirmed the effectiveness of the nurse-led alcohol guidance to control the HBP in male patients with hypertension during outpatient visits.

Public trials registry number: UMIN000017454 (UMIN Clinical Trials Registry).

Keywords: alcohol guidance; blood pressure; home morning blood pressure; hypertension; outpatient.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ambulatory Care
  • Blood Pressure / drug effects
  • Ethanol* / pharmacology
  • Ethanol* / therapeutic use
  • Humans
  • Hypertension* / nursing
  • Hypertension* / prevention & control
  • Male
  • Middle Aged
  • Treatment Outcome

Substances

  • Ethanol

Associated data

  • JPRN/UMIN000017454