More than an on-and-off switch: Post-translational modifications of plant pattern recognition receptor complexes

Curr Opin Plant Biol. 2021 Oct:63:102051. doi: 10.1016/j.pbi.2021.102051. Epub 2021 May 19.

Abstract

Sensing microbe-associated molecular patterns (MAMPs) by cell surface-resident pattern recognition receptors (PRRs) constitutes a core process in launching a successful immune response. Over the last decade, remarkable progress has been made in delineating the mechanisms of PRR-mediated plant immunity. As the frontline of defense, the homeostasis, activities, and subcellular dynamics of PRR and associated regulators are subjected to tight regulations. The layered protein post-translational modifications, particularly the intertwined phosphorylation and ubiquitylation of PRR complexes, play a central role in regulating PRR signaling outputs and plant immune responses. This review provides an update about the PRR complex regulation by various post-translational modifications and discusses how protein phosphorylation and ubiquitylation act in concert to ensure a rapid, proper, and robust immune response.

Keywords: MAMPs; PRR complex; Phosphorylation; Plant immunity; Post-translational modifications; Ubiquitylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Plant Immunity* / genetics
  • Plants / genetics
  • Plants / metabolism
  • Protein Processing, Post-Translational
  • Receptors, Pattern Recognition* / genetics
  • Receptors, Pattern Recognition* / metabolism
  • Signal Transduction

Substances

  • Receptors, Pattern Recognition