Advances in regulatory B cells in autoimmune thyroid diseases

Shaoyang Kang; Junning Kang; Haitao Shen; Na Wu

doi:10.1016/j.intimp.2021.107770

Advances in regulatory B cells in autoimmune thyroid diseases

Int Immunopharmacol. 2021 Jul:96:107770. doi: 10.1016/j.intimp.2021.107770. Epub 2021 May 19.

Authors

Shaoyang Kang¹, Junning Kang¹, Haitao Shen², Na Wu³

Affiliations

¹ Student Affairs Department, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China.
² Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China.
³ Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address: 3441535223@qq.com.

PMID: 34020391
DOI: 10.1016/j.intimp.2021.107770

Abstract

Regulatory B cells (Bregs) are a subset of B cells that can downregulate the immune and inflammatory responses. The development of B cells in humans and mice is differs. The Positioning and targeted regulation of Bregs has a positive effect on autoimmune diseases. Autoimmune thyroid disease (AITD) is a common autoimmune disease. This review introduces the history and origins of Bregs. It summarizes the different phenotypes and functionalities of Breg cells related to AITD and analyzes the reasons for the differences in Breg expression frequencies in Graves disease (GD) and Hashimoto's Thyroiditis (HT). A number of functional defects of regulatory B cells may be the newly discovered cause of AITD. This paper sheds new light on the role and prospects of Bregs in the progression and treatment of AITD.

Keywords: AITD; IL-10; Regulatory B cells.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / immunology*
B-Lymphocytes, Regulatory / immunology*
Graves Disease / immunology*
Graves Disease / therapy
Hashimoto Disease / immunology*
Hashimoto Disease / therapy
Humans