Improved Reactive Oxygen Species Generation by Chiral Co3 O4 Supraparticles under Electromagnetic Fields

Xiuxiu Wang; Maozhong Sun; Aihua Qu; Weiwei Wang; Meiru Lu; Xiao Guo; Chen Chen; Changlong Hao; Liguang Xu; Chuanlai Xu; Hua Kuang

doi:10.1002/anie.202105675

Improved Reactive Oxygen Species Generation by Chiral Co₃ O₄ Supraparticles under Electromagnetic Fields

Angew Chem Int Ed Engl. 2021 Aug 9;60(33):18240-18246. doi: 10.1002/anie.202105675. Epub 2021 Jul 26.

Authors

Xiuxiu Wang^{1

2}, Maozhong Sun^{1

2}, Aihua Qu^{1

2}, Weiwei Wang^{1

2}, Meiru Lu^{1

2}, Xiao Guo^{1

2}, Chen Chen^{1

2}, Changlong Hao^{1

2}, Liguang Xu^{1

2}, Chuanlai Xu^{1

2}, Hua Kuang^{1

2}

Affiliations

¹ Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, State Key Laboratory of Food Science and Technology, International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
² International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.

PMID: 34018664
DOI: 10.1002/anie.202105675

Abstract

One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease. The aim of this treatment was to initiate the lysis of fibrin; however, there are many side-effects associated with this form of treatment. Herein, we fabricated chiral Co₃ O₄ supraparticles (SPs) with a g-factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that d-SPs degraded blood clot within 8 hours under MF. Compared to l-SPs, d-SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 % in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced by d-SPs were 1.5 times higher than that of l-SPs, which might be attributed to the chiral-induced spin selectivity effects.

Keywords: Co3O4; chirality; electromagnetic fields; supraparticles; thrombosis.

Publication types

Research Support, Non-U.S. Gov't