Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma

Immunol Invest. 2022 Jul;51(5):1211-1221. doi: 10.1080/08820139.2021.1920609. Epub 2021 May 21.

Abstract

AFP: alpha-fetoprotein; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AURKA: aurora kinase A; BCLC: Barcelona- Clinic Liver Cancer; CBC: complete blood count; CT: computed tomography; DM: diabetes mellitus; DNA: deoxyribonucleic acid; EDTA: ethylene diamine tetraacetic acid; GGT: gamma-glutamyl transferase; HB: hemoglobin; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; INR: international normalized ratio; mRNA: messenger ribonucleic acid; OR: odds ratio; PVT: portal vein thrombosis; RT-PCR: real-time polymerase chain reaction; SNP: single nucleotide polymorphism; WBCs: white blood cells.

Keywords: Hepatocellular carcinoma (HCC); aurora kinase A (AURKA); hepatitis C virus (HCV); single nucleotide polymorphism (SNP).

MeSH terms

  • Aurora Kinase A* / genetics
  • Carcinoma, Hepatocellular* / genetics
  • Carcinoma, Hepatocellular* / pathology
  • Genetic Predisposition to Disease / genetics
  • Hepacivirus
  • Hepatitis B Surface Antigens / genetics
  • Hepatitis B virus / genetics
  • Hepatitis C
  • Humans
  • Liver Neoplasms* / genetics
  • Liver Neoplasms* / pathology
  • Polymorphism, Genetic

Substances

  • Hepatitis B Surface Antigens
  • AURKA protein, human
  • Aurora Kinase A