Analysis of the clinical effect of noninvasive mechanical ventilation in AIDS patients complicated with pneumonia

Changming Liu; Yan He; Gang Xiao; Hui Ouyang; Chan Zhang

Analysis of the clinical effect of noninvasive mechanical ventilation in AIDS patients complicated with pneumonia

Am J Transl Res. 2021 Apr 15;13(4):3794-3799. eCollection 2021.

Authors

Changming Liu¹, Yan He², Gang Xiao³, Hui Ouyang⁴, Chan Zhang⁴

Affiliations

¹ The Third Department of Infection, The First Hospital of Changsha Changsha, Hu'nan Province, China.
² Department of Infection, The Second Xiangya Hospital of Central South University Changsha, Hu'nan Province, China.
³ Department of AIDS, The First Hospital of Changsha Changsha, Hu'nan Province, China.
⁴ Department of Respiratory Medicine, The Fourth Hospital of Changsha Changsha, Hu'nan Province, China.

PMID: 34017567
PMCID: PMC8129412

Abstract

Objective: To explore the clinical application effect of noninvasive mechanical ventilation for patients with acquired immune deficiency syndrome (AIDS) complicated with pneumonia.

Methods: A prospective study was conducted on 86 patients with AIDS complicated with pneumocystis pneumonia. The patients were randomly divided into a control group and an experimental group, both of which were treated with conventional drugs. The control group was supplemented with oxygen via a mask, and the experimental group was additionally treated with noninvasive ventilator ventilation. The changes of arterial oxygen partial pressure, oxygenation index, respiratory frequency, pulse rate, serum albumin and other indicators between the two groups before and after treatment were observed. The patient's hospitalization time, overall improvement and mortality rate were compared.

Results: Compared with those before treatment, the arterial oxygen partial pressure, oxygenation index, respiratory frequency, and pulse rate of the two groups of patients were significantly improved after treatment (P<0.05). The improvement of the experimental group after treatment was more significant than that of the control group, and the difference was statistically significant (P<0.001). After treatment, the proportion of recovery rate of serum albumin in the experimental group was 81.40%, which was significantly higher than that in the control group (53.49%), and the difference was statistically significant (P<0.05). Compared with the control group, hospitalization time, treatment improvement and mortality rate in the experimental group had significant advantages and statistical significance (P<0.05).

Conclusion: For AIDS patients complicated with pneumonia, noninvasive mechanical ventilation had obvious treatment effects, which could significantly improve respiratory function, reduce mortality rate, and increase recovery rate. It can be considered as a therapeutic method to be included in routine treatment protocols.

Keywords: Acquired immune deficiency syndrome; clinical effect; noninvasive mechanical ventilation treatment; patients with comorbidities; pneumonia.