SGLT-2 inhibitor intervention in diabetes mellitus patients can reduce the incidence of renal injury and adverse events

Xiaoyan Tao; Tianrong Pan; Xing Zhong; Yijun Du; Ping Zhang

SGLT-2 inhibitor intervention in diabetes mellitus patients can reduce the incidence of renal injury and adverse events

Am J Transl Res. 2021 Apr 15;13(4):2731-2737. eCollection 2021.

Authors

Xiaoyan Tao¹, Tianrong Pan¹, Xing Zhong¹, Yijun Du¹, Ping Zhang¹

Affiliation

¹ Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University Hefei 236600, Anhui Province, China.

PMID: 34017435
PMCID: PMC8129378

Abstract

Objective: To explore the therapeutic value of sodium-dependent glucose transporters 2 (SGLT-2) inhibitor in type 2 diabetes mellitus (DM).

Methods: A total of 131 patients with type 2 DM admitted to our hospital from October 2017 to November 2019 were recruited as research objects, including 58 patients treated with insulin + metformin + acarbose as the control group (CG), and 73 patients treated with SGLT-2 inhibitor on the basis of control group as the study group (SG). The levels of blood glucose, serum creatinine (Scr), 24-hour urinary protein quantity, serum uric acid, and the incidence of adverse events were compared between the two groups.

Results: After treatment, fasting blood glucose (FPG), 2 hours postprandial blood glucose (2hPG), body mass index (BMI), hemoglobin A1c (HbA1c), type IV collagen (CIV), procollagen type III (PCIII), serum creatinine (Scr), 24-hour urinary protein quantity and blood uric acid (UA) decreased significantly (P > 0.05), and they were lower in SG than in CG (P < 0.05). Besides, the total effective rate of SG was 95.89%, which was notably higher than that of CG (84.48%, P < 0.05). The adverse reaction rate (ADR) of patients in SG was notably lower than that in CG (P < 0.05).

Conclusion: SGLT-2 inhibitor can effectively control the blood glucose level of DM patients, and can reduce the incidence of renal injury and adverse events.

Keywords: SGLT-2 inhibitor; adverse events; renal injury; type 2 diabetes mellitus.