Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity

Ziru Li; Ormond A MacDougald

doi:10.1016/j.beem.2021.101547

Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity

Best Pract Res Clin Endocrinol Metab. 2021 Jul;35(4):101547. doi: 10.1016/j.beem.2021.101547. Epub 2021 May 1.

Authors

Ziru Li¹, Ormond A MacDougald²

Affiliations

¹ Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
² Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: macdouga@med.umich.edu.

Abstract

Laboratory mice are a crucial preclinical model system for investigating bone marrow adipocyte (BMAd)-bone and BMAd-hematopoiesis interactions. In this review, we evaluate the suitability of mice to model common human diseases related to osteopenia or hematopoietic disorders, point out consistencies and discrepancies among different studies, and provide insights into model selection. Species, age, sex, skeletal site, and treatment protocol should all be considered when designing future studies.

Keywords: bone; bone marrow adipocyte; bone marrow adipose tissue; hematopoiesis; preclinical models.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adipocytes
Animals
Bone Marrow
Bone Marrow Cells*
Bone and Bones
Disease Models, Animal*
Humans
Mice

Abstract

Publication types

MeSH terms

Grants and funding