DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents

Senem Çitoğlu; Özlem Duyar Coşkun; Le Duc Tung; Mehmet Ali Onur; Nguyen Thi Kim Thanh

doi:10.2217/nnm-2020-0467

DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents

Nanomedicine (Lond). 2021 May;16(11):925-941. doi: 10.2217/nnm-2020-0467.

Authors

Senem Çitoğlu¹, Özlem Duyar Coşkun², Le Duc Tung^{3

4}, Mehmet Ali Onur⁵, Nguyen Thi Kim Thanh^{3

4}

Affiliations

¹ Department of Nanotechnology & Nanomedicine, Institute of Science, Hacettepe University, Beytepe, Ankara, 06800, Turkey.
² Thin Film Preparation and Characterization Laboratory, Department of Physics Engineering, Hacettepe University, Beytepe, Ankara, 06800, Turkey.
³ UCL Healthcare Biomagnetic & Nanomaterials Laboratories, The Royal Institution of Great Britain, 21 Albemarle Street, London, W1S 4BS, UK.
⁴ Biophysics Group, Department of Physics & Astronomy, University College London, Gower Street, London, WC1E 6BT, UK.
⁵ Department of Biology, Faculty of Science, Hacettepe University, Beytepe, Ankara, 06800, Turkey.

PMID: 34015971
DOI: 10.2217/nnm-2020-0467

Abstract

Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. Methods: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. Results: DMSA functionalized cubic IONPs with an edge length of 24.5 ± 1.9 nm had a specific absorption rate value of 197.4 W/g_Fe (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 × 10¹⁰, 6.6 × 10¹⁰ and 9.9 × 10¹⁰ NP/mL for 24, 48 and 72 h. Conclusion: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.

Keywords: HeLa; SAR; cytotoxicity; iron oxide cubic nanoparticles; meso-2,3-dimercaptosuccinic acid (DMSA).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ferric Compounds
HeLa Cells
Humans
Ligands
Magnetic Iron Oxide Nanoparticles
Magnetite Nanoparticles*
Nanoparticles*
Succimer

Substances

Ferric Compounds
Ligands
Magnetite Nanoparticles
Succimer