Multi-photon absorption organotin complex for bioimaging and promoting ROS generation

Changting Cai; Mengqi Lv; Pan Xiang; Chengjian Fang; Wen Ma; Xiaohe Tian; Xinsheng Xu; Yupeng Tian; Qiong Zhang

doi:10.1016/j.saa.2021.119923

Multi-photon absorption organotin complex for bioimaging and promoting ROS generation

Spectrochim Acta A Mol Biomol Spectrosc. 2021 Nov 5:260:119923. doi: 10.1016/j.saa.2021.119923. Epub 2021 May 18.

Authors

Changting Cai¹, Mengqi Lv², Pan Xiang², Chengjian Fang¹, Wen Ma¹, Xiaohe Tian², Xinsheng Xu³, Yupeng Tian¹, Qiong Zhang⁴

Affiliations

¹ Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Anhui University, Hefei 230601, PR China.
² School of Life Science, Anhui University, Hefei 230601, PR China.
³ School of Physics and Electronic Information, Anhui Normal University, Wuhu, Anhui 241000, PR China.
⁴ Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Anhui University, Hefei 230601, PR China; State Key Laboratory of Coordination Chemistry, Nanjing University, PR China. Electronic address: zhangqiong.314@163.com.

PMID: 34015744
DOI: 10.1016/j.saa.2021.119923

Abstract

Compared to general fluorescent dyes, multi-photon fluorescent dyes exhibit deeper tissue penetration and lower auto-fluorescence in the bio-imaging field. Therefore, it is necessary to develop an efficient multiphoton imaging agent for deep tissue imaging. In this work, an organotin derivative (HSnBu₃) has been designed and synthesized, which shows multiphoton absorption activity. In constrast to the ignorable three-photon activity of the ligand, the complex (HSnBu₃) exhibits three-photon activity under NIR excitation (1500 nm). Results of chemical and biological tests confirmed that HSnBu₃ was more easily activated by oxygen resulting in a higher level of ¹O₂, which could induce a decrease in mitochondrial membrane potential in HepG2 cells. It suggests that HSnBu₃ has potential in photodynamic therapy.

Keywords: Fluorescence imaging; Multi-photon; Organotin complex; ROS.

MeSH terms

Diagnostic Imaging
Fluorescent Dyes
Photochemotherapy*
Photons*
Reactive Oxygen Species

Substances

Fluorescent Dyes
Reactive Oxygen Species