Fast-Trk(B)ing the mechanism of antidepressants

Jacinta N Conroy; Dhanisha J Jhaveri; Elizabeth J Coulson

doi:10.1016/j.neuron.2021.04.027

Fast-Trk(B)ing the mechanism of antidepressants

Neuron. 2021 May 19;109(10):1593-1595. doi: 10.1016/j.neuron.2021.04.027. Epub 2021 May 12.

Authors

Jacinta N Conroy¹, Dhanisha J Jhaveri², Elizabeth J Coulson³

Affiliations

¹ School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
² Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
³ School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. Electronic address: e.coulson@uq.edu.au.

PMID: 34015266
DOI: 10.1016/j.neuron.2021.04.027

Abstract

The mechanism by which antidepressants elicit clinical improvements has proven elusive. In a recent publication in Cell, Casarotto et al. (2021) reveal a surprising direct interaction between antidepressants and TrkB. This link provides an important mechanistic insight into synaptic remodeling that may assist in the design of improved antidepressant therapeutics.

Publication types

Comment

MeSH terms

Antidepressive Agents / pharmacology
Nerve Growth Factors*
Protein Binding
Receptor, trkB* / metabolism
Signal Transduction / drug effects

Substances

Antidepressive Agents
Nerve Growth Factors
Receptor, trkB