TfOH-Promoted Decyanative Cyclization toward the Synthesis of 2,1-Benzisoxazoles

Mengge Zhang; Yonggang Meng; Yangang Wu; Chuanjun Song

doi:10.1021/acs.joc.1c00091

TfOH-Promoted Decyanative Cyclization toward the Synthesis of 2,1-Benzisoxazoles

J Org Chem. 2021 Jun 4;86(11):7326-7332. doi: 10.1021/acs.joc.1c00091. Epub 2021 May 20.

Authors

Mengge Zhang¹, Yonggang Meng¹, Yangang Wu¹, Chuanjun Song¹

Affiliation

¹ College of Chemistry and Green Catalysis Center, Zhengzhou University, Zhengzhou 450001, China.

PMID: 34014082
DOI: 10.1021/acs.joc.1c00091

Abstract

A novel solvent-free, TfOH-promoted decyanative cyclization approach for the synthesis of 2,1-benzisoxazoles has been developed. The reactions are complete instantly at room temperature and result in the formation of the desired 2,1-benzisoxazoles in a 34-97% isolated yield.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclization*
Molecular Structure
Solvents

Substances

Solvents