A terbium(iii)-bis(phthalocyaninato) neutral complex was deposited on the rutile TiO2(110) surface, and their interaction was studied by Scanning Tunneling Microscopy (STM) and X-ray Photoelectron Spectroscopy (XPS). It was found that the TiO2 rutile surface favours the adsorption of isolated molecules adopting a lying down configuration with the phthalocyanine planes tilted by about 30° when they lie in the first layer. The electronic and chemical properties of the molecules on the surface were studied by XPS as a function of the TiO2(110) substrate preparation. This study evidences that strong molecule-substrate interactions are present and a charge transfer process occurs from the molecule to the surface.