COVID-19 and Hypertension: The What, the Why, and the How

Shah-Abas Muhamad; Azizah Ugusman; Jaya Kumar; Dominik Skiba; Adila A Hamid; Amilia Aminuddin

doi:10.3389/fphys.2021.665064

COVID-19 and Hypertension: The What, the Why, and the How

Front Physiol. 2021 May 3:12:665064. doi: 10.3389/fphys.2021.665064. eCollection 2021.

Authors

Shah-Abas Muhamad¹, Azizah Ugusman¹, Jaya Kumar¹, Dominik Skiba², Adila A Hamid¹, Amilia Aminuddin¹

Affiliations

¹ Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
² Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Magdalenka, Poland.

Abstract

It has been a year since the coronavirus disease 2019 (COVID-19) was declared pandemic and wreak havoc worldwide. Despite meticulous research has been done in this period, there are still much to be learn from this novel coronavirus. Globally, observational studies have seen that majority of the patients with COVID-19 have preexisting hypertension. This raises the question about the possible relationship between COVID-19 and hypertension. This review summarizes the current understanding of the link between hypertension and COVID-19 and its underlying mechanisms.

Keywords: COVID-19; SARS-CoV-2; angiotensin converting enzyme 2; coronavirus; endothelial dysfunction; hypertension; renin angiotensin system.

Publication types

Review