Effect of dietary advanced glycation end-products restriction on type 2 diabetes mellitus control: a systematic review

Abstract

Context: Reducing dietary advanced glycation end-products (AGEs) may favor diabetes control.

Objective: Critically analyze studies about the effect of dietary AGEs restriction on inflammation, oxidative stress, and glycemic control in patients with type 2 diabetes mellitus (DM2).

Data source: This systematic review was conducted according to PRISMA methodology. The PubMed, Web of Science, LILACS, and Cochrane Library databases were searched, using the terms "type 2 diabetes," "advanced glycation end products" and "diet."

Data extraction: Seven original studies were included in this review. The duration of the studies ranged from 1 day to 16 weeks. All extracted data were compiled, compared, and critically analyzed.

Data analysis: Glycemic variables were considered the primary outcomes. The secondary outcomes were glycation, inflammatory, and oxidative stress markers.

Conclusion: Although serum insulin, homeostasis model assessment of insulin resistance, and glycated hemoglobin values were lower after the consumption of AGEs restricted diets in most studies, there was a lack of unanimity regarding dietary AGEs' positive effect on inflammation, oxidative stress, and blood glucose.

Systematic review registration: PROSPERO registration no. CRD42020152640.

Keywords: advanced glycation end products; diet; glucose; inflammation; type 2 diabetes mellitus.