Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

David C Bishop; Leighton E Clancy; Renee Simms; Jane Burgess; Geetha Mathew; Leili Moezzi; Janine A Street; Gaurav Sutrave; Elissa Atkins; Helen M McGuire; Brian S Gloss; Koon Lee; Wei Jiang; Karen Maddock; Georgia McCaughan; Selmir Avdic; Vicki Antonenas; Tracey A O'Brien; Peter J Shaw; David O Irving; David J Gottlieb; Emily Blyth; Kenneth P Micklethwaite

doi:10.1182/blood.2021010813

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

Blood. 2021 Oct 21;138(16):1504-1509. doi: 10.1182/blood.2021010813.

Authors

David C Bishop^{1

2

3

4}, Leighton E Clancy^{1

5}, Renee Simms^{1

2

5}, Jane Burgess^{1

2

5}, Geetha Mathew^{1

5}, Leili Moezzi^{1

5}, Janine A Street^{1

5}, Gaurav Sutrave^{1

2

3

4}, Elissa Atkins³, Helen M McGuire^{6

7

8}, Brian S Gloss¹, Koon Lee^{1

2}, Wei Jiang^{1

2}, Karen Maddock³, Georgia McCaughan^{2

3}, Selmir Avdic^{1

5}, Vicki Antonenas⁵, Tracey A O'Brien^{9

10

11}, Peter J Shaw^{12

13}, David O Irving^{14

15}, David J Gottlieb^{1

2

3

4

5}, Emily Blyth^{1

2

3

4

5}, Kenneth P Micklethwaite^{1

2

3

4

5}

Affiliations

¹ Westmead Institute for Medical Research, Sydney, NSW, Australia.
² Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
³ Department of Haematology , Westmead Hospital, Sydney, NSW, Australia.
⁴ Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, NSW, Australia.
⁵ Blood Transplant and Cell Therapies Laboratory, NSW Health Pathology-ICPMR Westmead, Sydney, NSW, Australia.
⁶ Ramaciotti Facility for Human Systems Biology, University of Sydney, Sydney, NSW, Australia.
⁷ Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
⁸ School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
⁹ Children's Cancer Institute, Sydney, NSW, Australia.
¹⁰ School of Women's & Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
¹¹ Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, Australia.
¹² BMT Services, Children's Hospital at Westmead, Sydney, NSW, Australia.
¹³ Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
¹⁴ Australian Red Cross Lifeblood, Sydney, NSW, Australia; and.
¹⁵ Faculty of Nursing, Midwifery & Health, University of Technology, Sydney, NSW, Australia.

PMID: 34010392
DOI: 10.1182/blood.2021010813

No abstract available

Publication types

Clinical Trial, Phase I
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
DNA Transposable Elements
Female
Hematopoietic Stem Cell Transplantation
Humans
Immunotherapy, Adoptive / adverse effects*
Immunotherapy, Adoptive / methods
Leukemia, B-Cell / genetics
Leukemia, B-Cell / therapy
Lymphoma / etiology*
Lymphoma / genetics
Lymphoma, B-Cell / genetics
Lymphoma, B-Cell / therapy
Male
Middle Aged
Receptors, Antigen, T-Cell / genetics
Receptors, Antigen, T-Cell / therapeutic use*
Treatment Outcome
Young Adult

Substances

CD19-specific chimeric antigen receptor
DNA Transposable Elements
Receptors, Antigen, T-Cell