Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review

L S Litvinova; K A Yurova; O G Khaziakhmatova; M Yu Khlusova; V V Malashchenko; E O Shunkin; N M Todosenko; I K Norkin; P A Ivanov; I A Khlusov

doi:10.1134/S1990750821020050

Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review

Biochem Mosc Suppl B Biomed Chem. 2021;15(2):147-152. doi: 10.1134/S1990750821020050. Epub 2021 May 14.

Authors

Affiliations

¹ Center for Immunology and Cellular Biotechnology of the Immanuel Kant Baltic Federal University, ul. Gaidarа 6, 236041 Kaliningrad, Russia.
² Division of Pathophysiology, Siberian State Medical University, ul. Uchebnaya 39, 634050 Tomsk, Russia.
³ Department of Morphology and General Pathology, Siberian State Medical University, Moskovsky Trakt 2, bldg. 7, 634050 Tomsk, Russia.
⁴ Research School of Chemistry and Applied Biomedical Sciences National Research Tomsk Polytechnic University, ul. Lenina 43-A, 634034 Tomsk, Russia.

Abstract

The review considers complex, controversial, and individual effects of heparin and its derivatives on the bone and circulatory systems in dependence of the dose, the state of the cells and tissues of the recipient. General data on the anticoagulant activity of heparin and its derivatives are presented; special attention is paid to the effect of heparin on mesenchymal cells and tissues and its role in angiogenesis. We also discuss the ability of heparin to bind osteogenic and angiogenic biomolecules in the context of the development of systems for their delivery and sustained controlled release and propose a schematic representation of the positive and side effects of heparin as a delivery system for biomolecules in tissue engineering.

Keywords: anticoagulant; bone tissue bioengineering; delivery system; hemostasis system; heparin; regenerative medicine.

© Pleiades Publishing, Ltd. 2021, ISSN 1990-7508, Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2021, Vol. 15, No. 2, pp. 147–152. © Pleiades Publishing, Ltd., 2021.Russian Text © The Author(s), 2020, published in Biomeditsinskaya Khimiya.