Familial chylomicronemia and multifactorial chylomicronemia

Abstract

The accumulation of chylomicrons in plasma beyond the postprandial period is a pathological event secondary to the partial or complete lack of activity of lipoprotein lipase that can lead to recurrent episodes of abdominal pain and acute pancreatitis. This article reviews the pathophysiology of this syndrome and the differential characteristics depending on whether it is due to congenital monogenic causes or acquired on a polygenic basis in which multiple factors may inluence.

Keywords: Chylomicronemia; Hipertrigliceridemia severa; Lipemic pancreatitis; Lipoprotein lipase; Lipoproteinlipasa; Pancreatitis lipémica; Quilomicronemia; Severe hypertriglyceridaemia.