Atypical antipsychotics play a limited role in the management of dementia-related psychosis (DRP). Major adverse outcomes are associated with most antipsychotics in patients with dementia, and guidelines recommend that these drugs not be prescribed for long durations. When treating symptoms of DRP, clinicians should follow guidelines such as using medication only if the patient or others are in distress or danger and starting with low doses. Novel antipsychotics or alternative agents may offer superior efficacy and safety.
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