Effects of SARS-CoV-2 infection on human reproduction

Ming Yang; Jing Wang; Yidong Chen; Siming Kong; Jie Qiao

doi:10.1093/jmcb/mjab025

Effects of SARS-CoV-2 infection on human reproduction

J Mol Cell Biol. 2021 Dec 30;13(10):695-704. doi: 10.1093/jmcb/mjab025.

Authors

Ming Yang^{1

2

3

4}, Jing Wang^{1

5}, Yidong Chen^{1

2

3

4}, Siming Kong^{1

2

3

4}, Jie Qiao^{1

5

2

6

3

7

4}

Affiliations

¹ Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.
² Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China.
³ Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
⁴ Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
⁵ National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China.
⁶ Beijing Advanced Innovation Center for Genomics, Beijing 100871, China.
⁷ Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Peking University, Beijing 100871, China.

Abstract

The worldwide infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacts human health and life on multiple levels. People infected with SARS-CoV-2 suffer from physical disorders and psychological distress. At present, no direct evidence indicates that SARS-CoV-2 negatively influences human reproduction, and the possibility that gametes and embryos are affected requires further investigation. To evaluate the potential effects of SARS-CoV-2 infection on human reproduction and fetal health, this review summarizes the basic and clinical research of SARS-CoV-2 on reproduction up to date, hoping to offer guidance and advice to people at reproductive age and provide clues for the prevention and treatment of associated diseases.

Keywords: COVID-19; SARS-CoV-2; reproduction; vertical transmission.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

COVID-19 / complications*
COVID-19 / epidemiology
COVID-19 / immunology
COVID-19 / virology
Humans
Reproduction / immunology*
SARS-CoV-2 / immunology*

Abstract

Publication types

MeSH terms

Grants and funding