Cutaneous Pseudolymphoma With Langerhans Cell Hyperplasia-A Rare Case With Clinical Presentation Mimicking Malignancy and Potential Diagnostic Pitfall

Cian-Hao Ye; Chih-Jung Chen; Kung-Chao Chang; Yu-Hung Wu; Mei-Ling Chen; Tsu-Man Chiu

doi:10.1097/DAD.0000000000001984

Cutaneous Pseudolymphoma With Langerhans Cell Hyperplasia-A Rare Case With Clinical Presentation Mimicking Malignancy and Potential Diagnostic Pitfall

Am J Dermatopathol. 2021 Dec 1;43(12):e280-e284. doi: 10.1097/DAD.0000000000001984.

Authors

Cian-Hao Ye^{1

2}, Chih-Jung Chen^{2

3}, Kung-Chao Chang^{4

5}, Yu-Hung Wu^{6

7}, Mei-Ling Chen⁸, Tsu-Man Chiu^{1

9}

Affiliations

¹ Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan.
² School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
³ Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
⁴ Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁵ Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
⁷ Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
⁸ Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan; and.
⁹ Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

PMID: 34001745
DOI: 10.1097/DAD.0000000000001984

Abstract

We describe a rare case of cutaneous pseudolymphoma with Langerhans cell hyperplasia. An 84-year-old female patient presented with erythematous and pernicious-looking plaques on her scalp that had been present for months. Histologically, lymphoid follicles consisting of mixed-type lymphocytes and Langerhans cells were aggregated focally. The diagnosis was verified by several immunohistochemical stains and by clinical evaluation. Skin lesions were steadily resolved with low-dose corticosteroid and hydroxychloroquine.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Diagnosis, Differential
Female
Humans
Hyperplasia / pathology
Langerhans Cells / pathology*
Lymphoma / diagnosis
Lymphoma / pathology
Pseudolymphoma / diagnosis*
Pseudolymphoma / pathology*
Scalp / pathology*
Skin Diseases / pathology*