VCAM-1 as a predictor biomarker in cardiovascular disease

Biochim Biophys Acta Mol Basis Dis. 2021 Sep 1;1867(9):166170. doi: 10.1016/j.bbadis.2021.166170. Epub 2021 May 14.

Abstract

The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically participates in the adhesion and transmigration of leukocytes to the interstitium during inflammation. VCAM-1 expression, together with soluble VCAM-1 (sVCAM-1) induced by the shedding of VCAM-1 by metalloproteinases, have been proposed as biomarkers in immunological diseases, cancer, autoimmune myocarditis, and as predictors of mortality and morbidity in patients with chronic heart failure (HF), endothelial injury in patients with coronary artery disease, and arrhythmias. This revision aims to discuss the role of sVCAM-1 as a biomarker to predict the occurrence, development, and preservation of cardiovascular disease.

Keywords: Atrial fibrillation; Biomarker; Cardiovascular diseases; VCAM-1; sVCAM-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism*
  • Cardiovascular Diseases / metabolism*
  • Humans
  • Myocarditis / metabolism
  • Vascular Cell Adhesion Molecule-1 / metabolism*

Substances

  • Biomarkers
  • Vascular Cell Adhesion Molecule-1