Lactate dehydrogenase to carboxyhemoglobin ratio as a biomarker of heme release to heme processing is associated with higher tricuspid regurgitant jet velocity and early death in sickle cell disease

Am J Hematol. 2021 Sep 1;96(9):E315-E318. doi: 10.1002/ajh.26243. Epub 2021 Jun 10.
No abstract available

Publication types

  • Clinical Trial
  • Letter
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adult
  • Anemia, Sickle Cell / blood*
  • Anemia, Sickle Cell / pathology
  • Biomarkers / analysis
  • Biomarkers / blood
  • Carbon Monoxide / analysis
  • Carboxyhemoglobin / analysis*
  • Heme / analysis*
  • Hemolysis
  • Humans
  • L-Lactate Dehydrogenase / blood*
  • Tricuspid Valve Insufficiency / blood
  • Tricuspid Valve Insufficiency / pathology

Substances

  • Biomarkers
  • Heme
  • Carbon Monoxide
  • Carboxyhemoglobin
  • L-Lactate Dehydrogenase

Associated data

  • ClinicalTrials.gov/NCT01547793
  • ClinicalTrials.gov/NCT00011648