EPHecting cell contact by increasing cortical tension

J Cell Biol. 2021 Jun 7;220(6):e202105015. doi: 10.1083/jcb.202105015. Epub 2021 May 17.

Abstract

EPH/EPHRIN signaling is crucial to the segregation of cell populations during the morphogenesis of many tissues. In this issue, Kindberg et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005216) show that EPH activation can drive both heterotypic cell repulsion and homotypic aggregation by triggering increased cortical tension.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Ephrins* / metabolism
  • Morphogenesis
  • Protein Binding
  • Protein Transport
  • Signal Transduction*

Substances

  • Ephrins