Metal-Free Direct C-H Functionalization of Quinoxalin-2(1 H)-Ones to Produce 3-Vinylated Quinoxalin-2(1 H)-Ones in the Presence of Alkenes

Abstract

A novel and efficient C ₃-H vinylation reaction with quinoxalin-2(1H)-one as the substrate, in the presence of alkenes, under metal-free conditions, is reported herein. The reaction leads to the formation of new carbon-carbon bonds that exhibit moderate to good reactivities. The vinylation of quinoxalin-2(1H)-ones, in the presence of alkenes, is an attractive process that can be potentially utilized to produce biologically active 3-vinylated quinoxalin-2(1H)-ones.

Keywords: C–H functionalization; alkenes; ammonium persulfate; cross-dehydrocoupling; vinylation.