Alagille syndrome and pregnancy

Adam Morton; Sailesh Kumar

doi:10.1177/1753495X19849738

Alagille syndrome and pregnancy

Obstet Med. 2021 Mar;14(1):39-41. doi: 10.1177/1753495X19849738. Epub 2019 Jun 9.

Authors

Adam Morton¹, Sailesh Kumar²

Affiliations

¹ Obstetric Medicine and University of Queensland, Mater Health, Brisbane, Australia.
² School of Medicine and Mater Research Institute, University of Queensland, South Brisbane, Australia.

Abstract

Alagille syndrome is an autosomal dominant multisystem disorder with an estimated frequency of 1 in 30 000. Only a small number of pregnancy outcomes have been described in women with this condition. The report details the pregnancy outcomes of two women with Alagille syndrome. We also review the literature pertaining to this syndrome in pregnancy and demonstrate a significant risk of adverse pregnancy outcomes.

Keywords: Alagille syndrome; intrauterine growth restriction; pregnancy.

Publication types

Case Reports