Mistakes Are Common; Should We Worry about Them?

Wendy P Robinson; Giulia F Del Gobbo

doi:10.1016/j.molmed.2021.04.008

Mistakes Are Common; Should We Worry about Them?

Trends Mol Med. 2021 Aug;27(8):721-722. doi: 10.1016/j.molmed.2021.04.008. Epub 2021 May 11.

Authors

Wendy P Robinson¹, Giulia F Del Gobbo²

Affiliations

¹ British Columbia (BC) Children's Hospital Research Institute, 950 W 28th Ave., Vancouver V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, 4500 Oak St., Vancouver V6H 3N1, Canada. Electronic address: wrobinson@bcchr.ca.
² British Columbia (BC) Children's Hospital Research Institute, 950 W 28th Ave., Vancouver V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, 4500 Oak St., Vancouver V6H 3N1, Canada.

PMID: 33994120
DOI: 10.1016/j.molmed.2021.04.008

Abstract

Mutations arising early in human development are surprisingly common, but most often are confined to the placenta. These mutations provide clues to the normal developmental processes leading to a healthy placenta, despite these features being shared in common with cancer.

Keywords: confined placental mosaicism; mosaicism; mutation; placenta; trophoblast.

Publication types

Review

MeSH terms

DNA Damage
Embryonic Development* / genetics
Female
Humans
Mosaicism*
Mutation*
Placenta / physiology*
Placentation
Pregnancy
Trophoblasts / metabolism