Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis

Circ Res. 2021 Jul 9;129(2):262-276. doi: 10.1161/CIRCRESAHA.120.318711. Epub 2021 May 17.

Abstract

[Figure: see text].

Keywords: blood pressure; gene expression; perfusion; phenotype; renin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Webcast

MeSH terms

  • Animals
  • Aortic Coarctation / genetics
  • Aortic Coarctation / metabolism*
  • Aortic Coarctation / pathology
  • Aortic Coarctation / physiopathology
  • Arterial Pressure*
  • Cell Line
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Cell Nucleus / pathology
  • Chromatin Assembly and Disassembly
  • Disease Models, Animal
  • Endocrine Cells / metabolism*
  • Endocrine Cells / pathology
  • Female
  • Homeostasis
  • Integrin beta1 / genetics
  • Integrin beta1 / metabolism
  • Kidney / metabolism*
  • Kidney / pathology
  • Kidney / physiopathology
  • Lamin Type A / genetics
  • Lamin Type A / metabolism
  • Male
  • Mechanotransduction, Cellular*
  • Mice
  • Mice, Knockout
  • Pressoreceptors / metabolism*
  • Pressoreceptors / physiopathology
  • Renin / genetics
  • Renin / metabolism*
  • Stress, Mechanical

Substances

  • Integrin beta1
  • Itgb1 protein, mouse
  • Lamin Type A
  • Lmna protein, mouse
  • Renin