Chinese guidelines on the clinical application of 5-aminolevulinic acid-based photodynamic therapy in dermatology (2021 edition)

Lei Shi; Hongwei Wang; Kun Chen; Jia Yan; Bo Yu; Shengchun Wang; Rui Yin; Xiang Nong; Xianbiao Zou; Zhou Chen; Chengxin Li; Liuqing Chen; Chunlei Zhang; Furen Zhang; Heyi Zheng; Min Zheng; Ping Tu; Jinhua Xu; Juan Tao; Xiaojing Kang; Kang Zeng; Yan Lu; Nan Yu; Xia Lei; Meng Pan; Qiang Ju; Heng Gu; Xiuli Wang

doi:10.1016/j.pdpdt.2021.102340

Chinese guidelines on the clinical application of 5-aminolevulinic acid-based photodynamic therapy in dermatology (2021 edition)

Photodiagnosis Photodyn Ther. 2021 Sep:35:102340. doi: 10.1016/j.pdpdt.2021.102340. Epub 2021 May 12.

Authors

Lei Shi¹, Hongwei Wang², Kun Chen³, Jia Yan¹, Bo Yu⁴, Shengchun Wang⁵, Rui Yin⁶, Xiang Nong⁷, Xianbiao Zou⁸, Zhou Chen⁹, Chengxin Li¹⁰, Liuqing Chen¹¹, Chunlei Zhang¹², Furen Zhang¹³, Heyi Zheng¹⁴, Min Zheng¹⁵, Ping Tu¹⁶, Jinhua Xu¹⁷, Juan Tao¹⁸, Xiaojing Kang¹⁹, Kang Zeng²⁰, Yan Lu²¹, Nan Yu²², Xia Lei²³, Meng Pan²⁴, Qiang Ju²⁵, Heng Gu²⁶, Xiuli Wang²⁷

Affiliations

¹ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
² Department of Dermatology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
³ Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu, China.
⁴ Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
⁵ Department of Dermatology, Xijing Hospital, Fourth Medical University, Xi'an, China.
⁶ Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China.
⁷ Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
⁸ Department of Dermatology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, China.
⁹ Department of Dermatology, Peking University People's Hospital, Beijing, China.
¹⁰ Department of Dermatology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
¹¹ Department of Dermatology, Wuhan NO.1 Hospital, Hubei, China.
¹² Department of Dermatology, Peking University Third Hospital, Beijing, China.
¹³ Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
¹⁴ Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁵ Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
¹⁶ Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
¹⁷ Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
¹⁸ Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China.
¹⁹ Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
²⁰ Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
²¹ Department of Dermatology, 1st Affiliated Hospital, Nanjing Medical University, Nanjing, China.
²² Department of Dermatology, General Hospital of Ningxia Medical University, Ningxia, China.
²³ Department of Dermatology, Daping Hospital, Army Medical University (Army Medical Center of PLA), Chongqing, China.
²⁴ Department of Dermatology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
²⁵ Department of Dermatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
²⁶ Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu, China. Electronic address: guheng@aliyun.com.
²⁷ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: wangxiuli20150315@163.com.

PMID: 33991660
DOI: 10.1016/j.pdpdt.2021.102340

Abstract

Photodynamic Therapy with 5-aminolevulinic acid (ALA-PDT) has been widely applied in the treatment of skin diseases in China. To further standardize, guide, and promote the clinical applications of ALA-PDT in dermatology, the Chinese Society of Dermatology, Chinese Association of Rehabilitation Dermatology, Photomedicine Therapeutic Equipment Group of Committee on Skin Disease, and Cosmetic Dermatology of China Association of Medical Equipment invited relevant experts engaged in ALA-PDT to revise and update the first edition of "Clinical application of 5-aminolevulinic acid-based photodynamic therapy: an expert consensus statement" and establish a more current edition, to provide an updated reference for Chinese dermatologists in clinical practice. In the guideline, the expert group reached consensus opinions on ALA-PDT with regard to mechanisms of action, therapeutic protocol, clinical applications, adverse reactions and countermeasures, precautions, care, and evaluation of efficacy.

Keywords: 5-Aminolevulinic acid; ALA-PDT; Clinical application; Dermatology; Guideline; Photodynamic therapy.

Publication types

Review

MeSH terms

Aminolevulinic Acid / therapeutic use
China
Dermatology*
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use

Substances

Photosensitizing Agents
Aminolevulinic Acid