Amide Proton Transfer-Weighted Imaging and Multiple Models Diffusion-Weighted Imaging Facilitates Preoperative Risk Stratification of Early-Stage Endometrial Carcinoma

Nan Meng; Ting Fang; Pengyang Feng; Zhun Huang; Jing Sun; Xuejia Wang; Jie Shang; Kaiyu Wang; Dongming Han; Meiyun Wang

doi:10.1002/jmri.27684

Amide Proton Transfer-Weighted Imaging and Multiple Models Diffusion-Weighted Imaging Facilitates Preoperative Risk Stratification of Early-Stage Endometrial Carcinoma

J Magn Reson Imaging. 2021 Oct;54(4):1200-1211. doi: 10.1002/jmri.27684. Epub 2021 May 15.

Authors

Nan Meng^{1

2}, Ting Fang^{1

2}, Pengyang Feng³, Zhun Huang³, Jing Sun⁴, Xuejia Wang⁵, Jie Shang⁶, Kaiyu Wang⁷, Dongming Han⁵, Meiyun Wang^{1

2}

Affiliations

¹ Department of Medical Imaging, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, China.
² Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
³ Department of Medical Imaging, Henan University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, China.
⁴ Department of Pediatrics, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, China.
⁵ Department of MR, the First Affiliated Hospital, Xinxiang Medical University, Weihui, China.
⁶ Department of Pathology, the First Affiliated Hospital, Xinxiang Medical University, Weihui, China.
⁷ MR Research China, GE Healthcare, Beijing, China.

PMID: 33991377
DOI: 10.1002/jmri.27684

Abstract

Background: Endometrial carcinoma (EC) risk stratification is generally based on histological assessment. It would be beneficial to perform risk stratification noninvasively by MRI.

Purpose: To investigate the application of amide proton transfer-weighted imaging (APTWI), monoexponential, biexponential, and stretched exponential intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) for the evaluation of risk stratification in early-stage EC.

Study type: Prospective.

Population: Eighty patients with early-stage EC (47 classified as low risk, 20 as medium risk, and 13 as high risk by histological grade and International Federation of Gynecology and Obstetrics stage).

Field strength/sequence: T1-weighted imaging, T2-weighted imaging, IVIM, APTWI, and DKI MRI at 3 T.

Assessment: The magnetization transfer ratio asymmetry (MTRasym [3.5 ppm]), apparent diffusion coefficient (ADC), diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient (DDC), water molecular diffusion heterogeneity index (α), mean kurtosis (MK), and mean diffusivity (MD) were calculated and compared between low-risk and non-low-risk groups.

Statistical tests: Individual sample t test, analysis of variance, and logistic regression. A P-value <0.05 was considered statistically significant.

Results: The α, ADC, D, DDC, and MD were significantly higher and the f, MK, and MTRasym (3.5 ppm) were significantly lower in the low-risk group than in the non-low-risk group. The difference in D* between the two groups was not significant (P = 0.289). MTRasym (3.5 ppm), D, and MK were independent predictors of risk stratification. The combination of these three parameters was better able to identify low- and non-low-risk groups than each individual parameter.

Data conclusion: The IVIM, DKI, and APTWI parameters have potential as imaging markers for risk stratification in early-stage EC.

Level of evidence: 2 TECHNICAL EFFICACY: Stage 3.

Keywords: amide proton transfer-weighted imaging; diffusion kurtosis imaging; endometrial carcinoma; intravoxel incoherent motion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides
Diffusion Magnetic Resonance Imaging
Endometrial Neoplasms* / diagnostic imaging
Female
Humans
Prospective Studies
Protons*
Risk Assessment

Substances

Amides
Protons