Progerin mRNA expression is elevated in aged human dermis and impairs TGF-β/Smad signaling

J Dermatol Sci. 2021 Jul;103(1):49-52. doi: 10.1016/j.jdermsci.2021.04.005. Epub 2021 Apr 26.

Authors

Yaping Xiang¹, Zhaoping Qin¹, Chunfang Guo¹, Tianyuan He¹, Yingchun Liu¹, Taihao Quan²

Affiliations

¹ Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
² Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: thquan@umich.edu.

PMID: 33985864
DOI: 10.1016/j.jdermsci.2021.04.005

No abstract available

Keywords: Progerin; Skin aging; TGF-β/Smad signaling.

Publication types

Comparative Study
Letter

MeSH terms

Adult
Age Factors
Aged
Aged, 80 and over
Biopsy
Cells, Cultured
Dermis / metabolism*
Fibroblasts
Humans
Lamin Type A / genetics
Lamin Type A / metabolism*
Male
Phosphorylation
Primary Cell Culture
Progeria / genetics
Progeria / pathology
RNA, Messenger / metabolism
Signal Transduction / physiology
Skin Aging / genetics*
Smad3 Protein / metabolism
Transforming Growth Factor beta1 / metabolism
Young Adult

Substances

Lamin Type A
RNA, Messenger
SMAD3 protein, human
Smad3 Protein
TGFB1 protein, human
Transforming Growth Factor beta1
prelamin A