Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines

Masashi Mizumoto; Hiroshi Fuji; Mitsuru Miyachi; Toshinori Soejima; Tetsuya Yamamoto; Norihiro Aibe; Yusuke Demizu; Hiromitsu Iwata; Takayuki Hashimoto; Atsushi Motegi; Atsufumi Kawamura; Keita Terashima; Takashi Fukushima; Tomohei Nakao; Akinori Takada; Minako Sumi; Junjiro Oshima; Kensuke Moriwaki; Miwako Nozaki; Yuji Ishida; Yoshiyuki Kosaka; Keisuke Ae; Ako Hosono; Hideyuki Harada; Etsuyo Ogo; Tetsuo Akimoto; Takashi Saito; Hiroko Fukushima; Ryoko Suzuki; Mitsuru Takahashi; Takayuki Matsuo; Akira Matsumura; Hidekazu Masaki; Hajime Hosoi; Naoyuki Shigematsu; Hideyuki Sakurai

doi:10.1016/j.ctrv.2021.102209

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines

Cancer Treat Rev. 2021 Jul:98:102209. doi: 10.1016/j.ctrv.2021.102209. Epub 2021 Apr 16.

Authors

Masashi Mizumoto¹, Hiroshi Fuji², Mitsuru Miyachi³, Toshinori Soejima⁴, Tetsuya Yamamoto⁵, Norihiro Aibe⁶, Yusuke Demizu⁴, Hiromitsu Iwata⁷, Takayuki Hashimoto⁸, Atsushi Motegi⁹, Atsufumi Kawamura¹⁰, Keita Terashima¹¹, Takashi Fukushima¹², Tomohei Nakao¹³, Akinori Takada¹⁴, Minako Sumi¹⁵, Junjiro Oshima¹⁶, Kensuke Moriwaki¹⁷, Miwako Nozaki¹⁸, Yuji Ishida¹⁹, Yoshiyuki Kosaka²⁰, Keisuke Ae²¹, Ako Hosono²², Hideyuki Harada²³, Etsuyo Ogo²⁴, Tetsuo Akimoto⁹, Takashi Saito¹, Hiroko Fukushima²⁵, Ryoko Suzuki²⁵, Mitsuru Takahashi²⁶, Takayuki Matsuo²⁷, Akira Matsumura²⁸, Hidekazu Masaki²⁹, Hajime Hosoi³, Naoyuki Shigematsu³⁰, Hideyuki Sakurai³¹

Affiliations

¹ Departments of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
² Department of Radiology and National Center for Child Health and Development, Tokyo, Japan.
³ Department of Pediatrics, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.
⁴ Department of Radiation Oncology, Hyogo Ion Beam Medical Center Kobe Proton Center, Kobe, Hyogo, Japan.
⁵ Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan.
⁶ Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
⁷ Department of Radiation Oncology, Nagoya Proton Therapy Center, Nagoya City University West Medical Center, Nagoya, Aichi, Japan.
⁸ Department of Radiation Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
⁹ Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, Japan.
¹⁰ Department of Neurosurgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Hyogo, Japan.
¹¹ Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
¹² Department of Pediatric Hematology and Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
¹³ Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan.
¹⁴ Department of Radiology, Mie University Hospital, Tsu-shi, Mie, Japan.
¹⁵ Department of Radiation Oncology and Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Radiation Oncology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
¹⁶ Matsumoto Pediatrics, Sapporo, Hokkaido, Japan.
¹⁷ Department of Medical Statistics, Kobe Pharmaceutical University, Kobe, Hyogo, Japan.
¹⁸ Department of Radiology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan.
¹⁹ Department of Pediatrics, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan.
²⁰ Department of Hematology and Oncology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Hyogo, Japan.
²¹ Department of Orthopaedic Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
²² Department of Pediatric Oncology, National Cancer Center Hospital East, Chiba, Japan.
²³ Division of Radiation Therapy, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan.
²⁴ Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
²⁵ Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
²⁶ Department of Orthopaedic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan.
²⁷ Department of Neurosurgery, Nagasaki University Graduate School of Medicine, Nagasaki, Japan.
²⁸ Departments of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, Japan.
²⁹ Proton Therapy Center, Aizawa Hospital, Matsumoto, Nagano, Japan.
³⁰ Department of Radiology, Keio University School of Medicine, Tokyo, Japan.
³¹ Departments of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: hsakurai@pmrc.tsukuba.ac.jp.

PMID: 33984606
DOI: 10.1016/j.ctrv.2021.102209

Abstract

Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor. To define the outcomes and characteristics of PBT in cancer treatment in pediatric and AYA patients, this document was developed by the Japanese Society for Radiation Oncology (JASTRO) and the Japanese Society of Pediatric Hematology/Oncology (JSPHO).

Keywords: AYA; Children; Guideline; Pediatric; Proton beam therapy.

Publication types

Review

MeSH terms

Adolescent
Adult
Child
Humans
Neoplasms / pathology
Neoplasms / radiotherapy*
Practice Guidelines as Topic / standards*
Proton Therapy / methods*
Societies, Medical
Young Adult