As sequencing technology and information of the genomic causes for cancer development expand, multi-gene panel testing for hereditary cancer is increasing in clinical practice. In this chapter, we reviewed the application of multi-gene panel with pre-/post- testing considerations and summarized genetic counseling based on panel testing results in clinical field. In addition, we introduce multi-gene panel for hereditary cancer developed in Seoul National University Hospital.
Keywords: BRCA1/2 gene mutation; Breast cancer susceptibility; Genetic counseling; Hereditary/familial breast cancer; High penetrance gene; Multigene panel testing; Next-generation sequencing.