Regional lung viscoelastic properties in supine and prone position in a porcine model of acute respiratory distress syndrome

Abstract

Regional viscoelastic properties of thoracic tissues in acute respiratory distress syndrome (ARDS) and their change with position and positive end-expiratory pressure (PEEP) are unknown. In an experimental porcine ARDS, dorsal and ventral lung (R₂,L and E₂,L) and chest wall (R₂,cw and E₂,cw) viscoelastic resistive (R) and elastic (E) parameters were measured at 20, 15, 10, and 5 cmH₂O PEEP in supine and prone position. E₂ and R₂ were obtained by fitting the decay of pressure after end-inspiratory occlusion to the equation: P_viscmax (t) =R₂ e^-t/τ₂, where t is the length of occlusion and τ₂ time constant. E₂ was equal to R₂/τ₂. R₂,cw and E₂,cw were measured from esophageal, dorsal, and ventral pleural pressures. Global R₂,L and E₂,L were obtained from the global transpulmonary pressure (airway pressure-esophageal pressure), and regional R₂,L and E₂,L from the dorsal and ventral airway pressure-pleural pressure difference. Lung ventilation was measured by electrical impedance tomography (EIT). Global R₂,cw and E₂,cw did not change with PEEP or position. Global R₂,L [median(Q1-Q3)] was 37.1 (11.0-65.1), 5.1 (4.3-5.5), 12.1 (8.4-19.5), and 41.0 (26.6-53.5) cmH₂O/L/s in supine, and 15.3 (9.1-41.9), 7.9 (5.7-11.0), 8.0 (5.1-12.1), and 12.9 (6.4-19.4) cmH₂O/L in prone from 20 to 5 cmH₂O PEEP (P = 0.06 for PEEP and P = 0.06 for position). Dorsal R₂,L significantly and positively correlated with the amount of collapse measured with EIT. Global and regional lung and chest wall viscoelastic parameters can be described by a simple rheological model. Regional E₂ and R₂ were uninfluenced by PEEP and position except for PEEP on dorsal E₂,L and position on dorsal E₂,cw.NEW & NOTEWORTHY In a porcine model of acute respiratory distress syndrome, data were successfully fitted to a rheological model of the nonlinear behavior of viscoelastic properties of lung and chest wall at different positive end-expiratory pressure (PEEP) in the supine and prone position. Prone position tended to decrease lung viscoelastic resistive component. PEEP had a significant effect on dorsal lung viscoelastic elastance. Finally, lung viscoelastic resistance correlated with the amount of lung collapse assessed by electrical impedance tomography.

Keywords: acute respiratory distress syndrome; pleural pressure; positive end-expiratory pressure; prone position; viscoelasticity.