New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk

Logan K Townsend; Rebecca E K MacPherson; David C Wright

doi:10.1210/clinem/dgab333

New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk

J Clin Endocrinol Metab. 2021 Jul 13;106(8):2147-2163. doi: 10.1210/clinem/dgab333.

Authors

Logan K Townsend^{1

2}, Rebecca E K MacPherson³, David C Wright²

Affiliations

¹ Department of Medicine, McMaster University, Hamilton, L8S 4L8, Canada.
² Department of Human Health and Nutritional Science, University of Guelph, Guelph, N1G 2W1, Canada.
³ Department of Health Sciences and Centre for Neuroscience, Brock University, St. Catharines, L2S 3A1, Canada.

PMID: 33982072
DOI: 10.1210/clinem/dgab333

Abstract

The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.

Keywords: BDNF; FGF21; GDF15; GPLD1; brain; exercise; irisin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptation, Physiological / physiology*
Aging / physiology
Brain / physiology*
Exercise / physiology*
Fibronectins / metabolism
Humans

Substances

Fibronectins

Grants and funding

CIHR/Canada