Assessing Agreement between Frequency-Specific Chirp Auditory Steady-State Response and Pure Tone Audiometry in Adults by Intraclass Correlation Coefficient

Mo Chen; Yi Wei; Xianren Wang; Liman Liu; Min Liu; Guangli Jiang; Fanqin Wei

doi:10.1159/000515237

Assessing Agreement between Frequency-Specific Chirp Auditory Steady-State Response and Pure Tone Audiometry in Adults by Intraclass Correlation Coefficient

ORL J Otorhinolaryngol Relat Spec. 2022;84(1):30-38. doi: 10.1159/000515237. Epub 2021 May 12.

Authors

Mo Chen^{1

2

3}, Yi Wei^{1

2

3}, Xianren Wang^{1

2

3}, Liman Liu^{1

2

3}, Min Liu^{1

2

3}, Guangli Jiang^{1

2

3}, Fanqin Wei^{1

2

3}

Affiliations

¹ Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
² Institute of Otorhinolaryngology Head and Neck Surgery, Sun Yat-sen University, Guangzhou, China.
³ Guangzhou Key Laboratory of Otorhinolarygology, Guangzhou, China.

PMID: 33979798
DOI: 10.1159/000515237

Abstract

Introduction: Chirp auditory steady-state response (ASSR) can be used to assess frequency-specific hearing thresholds. However, its reliability has not been confirmed yet. The purpose of this proposed study is to analyze the agreement of thresholds measured by chirp-ASSR and pure tone audiometry (PTA) to investigate the value of chirp-ASSR in hearing threshold evaluation.

Methods: Participants with normal hearing (age: 18-66, 108 ears) and patients with sensorineural hearing loss (age: 22-82, 75 ears) were tested using PTA and chirp-ASSR at 0.5, 1, 2, and 4 kHz, respectively. Intraclass correlation coefficient (ICC) and Bland-Altman plot were introduced to analyze the agreement between the 2 methods.

Results: One-hundred eight participants underwent both chirp-ASSR and PTA to estimate their thresholds. The ICCs yielded by these 2 methods are 0.757, 0.893, 0.883, and 0.921 (p < 0.001) at 0.5, 1, 2, and 4 kHz carrier frequency, respectively. However, there is a significant difference between the 2 methods at 2 kHz: the mean value of the ASSR thresholds is 5.27 dB HL higher than the value of PTA thresholds. Additionally, the 95% limits of agreement range from -27.48 to 26.66 dB HL at 0.5 kHz, from -18.19 to 17.87 dB HL at 1 kHz, from -12.01 to 22.55 dB HL at 2 kHz, and from -21.29 to 19.17 dB HL at 4 kHz, which are large enough to affect clinical decision-making.

Conclusion: In this study, we have confirmed good to excellent correlation between chirp-ASSR and PTA in threshold estimation for adults with and without hearing loss. The degree of correlations is higher for participants with hearing loss and for measurements at high frequencies. However, significant systematic difference and large limits of agreement between the 2 methods have been found. These findings show that chirp-ASSR can be treated as a supplementary method to PTA when evaluating the hearing level, but the 2 methods are not interchangeable due to their systematic difference and large limits of agreement.

Keywords: Agreement between methods; Bland-Altman plot; Chirp auditory steady-state response; Intraclass correlation coefficient; Pure tone audiometry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acoustic Stimulation / methods
Adolescent
Adult
Audiometry, Pure-Tone
Auditory Threshold / physiology
Evoked Potentials, Auditory, Brain Stem / physiology
Hearing / physiology
Hearing Loss* / diagnosis
Hearing Loss, Sensorineural* / diagnosis
Humans
Reproducibility of Results
Young Adult