The popularity of nanotechnology results from the possibility of obtaining materials that have better chemical, electrical, thermal, mechanical, or optical properties. Nano-sized materials are characterized by an increased surface area, which improves their chemical reactivity and mobility. Due to their enhanced reactivity and appropriately small size, some nanoparticles are used as antimicrobial and antifungal agents. Nanoparticles exhibit antimicrobial potential through multifaceted mechanisms. The adhesion of nanoparticles to microbial cells, and reactive oxygen species, and their penetration inside the cells, have been recognized as the most prominent modes of antimicrobial action. This review presents the mechanism of action of nanometals and oxide nanoparticles used as antimicrobials and the mechanisms of bacterial resistance to the toxic effects of nanoparticles. The article presents methods of forming microorganism resistance to the toxic effects of nanoparticles and the negative impact of nanoparticles on human health.
Keywords: Metal particles; bacterial resistance; biocidal activities; exposure; metal oxides; nanosized particles.