Inherited Variants in SCARB1 Cause Severe Early-Onset Coronary Artery Disease

Circ Res. 2021 Jul 9;129(2):296-307. doi: 10.1161/CIRCRESAHA.120.318793. Epub 2021 May 12.

Sara N Koenig^{1

2}, Holly C Sucharski^{1

2}, Elizabeth M Jose^{1

2}, Emma K Dudley^{1

2}, Francesca Madiai^{1

3}, Omer Cavus^{1

2}, Aaron D Argall^{1

2}, Jordan L Williams^{1

2}, Nathaniel P Murphy^{1

2}, Caullin B R Keith^{1

2}, Mona El Refaey^{1

2}, Richard J Gumina^{1

3}, Konstantinos D Boudoulas³, M Wesley Milks³, Gbemiga Sofowora³, Sakima A Smith^{1

2

3}, Thomas J Hund^{1

2}, Nathan T Wright⁴, Elisa A Bradley^{1

3}, Karolina M Zareba³, Loren E Wold^{1

2

5}, Ernest L Mazzaferri Jr^{1

3}, Peter J Mohler^{1

2

3}

¹ Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
² Department of Physiology and Cell Biology (S.N.K., H.C.S., E.M.J., E.K.D., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., S.A.S., T.J.H., L.E.W., P.J.M.), The Ohio State University, Columbus.
³ Ross Heart Hospital, The Ohio State University College of Medicine and Wexner Medical Center (F.M., R.J.G., K.D.B., M.W.M., G.S., S.A.S., E.A.B., K.M.Z., E.L.M., P.J.M.), The Ohio State University, Columbus.
⁴ Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA (N.T.W.).
⁵ College of Nursing (L.E.W.), The Ohio State University, Columbus.

Abstract

[Figure: see text].

Keywords: cholesterol, high-density lipoprotein; coronary disease; dyslipidemia; genetics; human; physiology.