Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin

Yao Zhou; Diyin Li; Jianhua Luo; Aizhong Chen; Xingxing Li; Zhenrui Pan; Li Wan; Liuqing He; Danyang Li; Yanyan Li; Min Dong; Liang Tao

doi:10.1038/s41422-021-00510-z

Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin

Cell Res. 2021 Aug;31(8):935-938. doi: 10.1038/s41422-021-00510-z. Epub 2021 May 10.

Authors

Yao Zhou^#^{1

2

3}, Diyin Li^#^{1

2

3}, Jianhua Luo^#^{1

2

3}, Aizhong Chen^{1

2

3}, Xingxing Li^{1

2

3}, Zhenrui Pan^{1

2

3}, Li Wan^{1

2

3}, Liuqing He^{1

2

3}, Danyang Li^{1

2

3}, Yanyan Li^{1

2

3}, Min Dong^{4

5}, Liang Tao^{6

7

8}

Affiliations

¹ Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
² Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
³ Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
⁴ Department of Urology, Boston Children's Hospital, Boston, MA, USA.
⁵ Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA, USA.
⁶ Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. taoliang@westlake.edu.cn.
⁷ Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. taoliang@westlake.edu.cn.
⁸ Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. taoliang@westlake.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Toxins*
Glycosaminoglycans
Lipoproteins, LDL

Substances

Bacterial Toxins
Clostridium novyi alpha-toxin
Glycosaminoglycans
Lipoproteins, LDL
A73025

Publication types

MeSH terms

Substances

Grants and funding