Detection of CTX-M-27 β-Lactamase Genes on Two Distinct Plasmid Types in ST38 Escherichia coli from Three U.S. States

Andrew Cameron; Rupinder Mangat; Heba H Mostafa; Samantha Taffner; Jun Wang; Ghinwa Dumyati; Richard A Stanton; Jonathan B Daniels; Davina Campbell; Joseph D Lutgring; Nicole D Pecora

doi:10.1128/AAC.00825-21

Detection of CTX-M-27 β-Lactamase Genes on Two Distinct Plasmid Types in ST38 Escherichia coli from Three U.S. States

Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0082521. doi: 10.1128/AAC.00825-21. Epub 2021 Jun 17.

Authors

Affiliations

¹ University of Rochester Medical Center, Clinical Microbiology, Department of Pathology and Laboratory Medicine, Rochester, New York, USA.
² University of Rochester Medical Center, Department of Medicine, Infectious Diseases Division, Rochester, New York, USA.
³ Department of Pathology, Division of Medical Microbiology, Johns Hopkins Medicine, Baltimore, Maryland, USA.
⁴ Center for Community Health and Prevention, University of Rochester, Rochester, New York, USA.
⁵ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

^# Contributed equally.

Abstract

Infections caused by extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli are a significant cause of morbidity and health care costs. Globally, the prevailing clonal type is ST131 in association with the bla_CTX-M-15 β-lactamase gene. However, other ESBLs, such as bla_CTX-M-14 and bla_CTX-M-27, can also be prevalent in some regions. We identified ST38 ESBL-producing E. coli from different regions in the United States which carry bla_CTX-M-27 embedded on two distinct plasmid types, suggesting the potential emergence of new ESBL lineages.

Keywords: CTX-M-27; ESBL; Escherichia coli; IncF plasmid; ST38; ceftriaxone; extended-spectrum β-lactamases; β-lactamases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli / genetics
Escherichia coli Infections* / drug therapy
Escherichia coli Proteins* / genetics
Humans
Plasmids / genetics
United States
beta-Lactamases / genetics

Substances

Escherichia coli Proteins
beta-Lactamases