Multicolor fluorescence biosensors reveal a burning need for diversity in the single-cell metabolic landscape

Trends Endocrinol Metab. 2021 Aug;32(8):537-539. doi: 10.1016/j.tem.2021.04.002. Epub 2021 May 7.

Abstract

Although cellular heterogeneity has been described for metabolic pathways, the upstream mechanisms, the downstream consequences, and the flexibility and transmission of these preferences to daughter cells remains largely unknown. Using live-cell imaging, Kosaisawe et al. demonstrate that cellular metabolism, determined by glycolysis and ATP, is spontaneously heterogeneous, plastic, and regulatory.

Keywords: fluorescence biosensors; metabolic heterogeneity; single cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenosine Triphosphate
  • Biosensing Techniques*
  • Glycolysis*
  • Metabolic Networks and Pathways*

Substances

  • Adenosine Triphosphate