Metabolic regulation on the immune environment of glioma through gut microbiota

Yingying Lyu; Hui Yang; Liang Chen

doi:10.1016/j.semcancer.2021.05.005

Metabolic regulation on the immune environment of glioma through gut microbiota

Semin Cancer Biol. 2022 Nov;86(Pt 2):990-997. doi: 10.1016/j.semcancer.2021.05.005. Epub 2021 May 7.

Authors

Yingying Lyu¹, Hui Yang², Liang Chen³

Affiliations

¹ Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR China; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, PR China; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, PR China. Electronic address: hui_yang@fudan.edu.cn.
³ Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR China; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, PR China. Electronic address: hschenliang@fudan.edu.cn.

PMID: 33971263
DOI: 10.1016/j.semcancer.2021.05.005

Abstract

The gut-brain axis has paved our way in understanding varieties of disease. The gut microbiota especially the bacterial population plays critical roles in immune system development and function. Glioma comprises 80 percent of malignant brain cancer and glioblastoma (GBM) is the most malignant kind. GBM has a reputation for its suppressive immune environment and poor patient prognosis. Moreover, altered metabolites from gut microbiota affect both systemic immune and central nervous system (CNS) immunity. Here we will focus on the crosstalk between gut microbiota and GBM, and further explore how this communication contributes to glioma initiation and development. Finally, we highlight the latest insights on the metabolic regulation of immunity through gut microbiota, which provides a promising therapeutic strategy for GBM.

Keywords: Glioma; Gut microbiota; Gut-brain axis; Immune; Metabolites.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms*
Gastrointestinal Microbiome*
Glioma* / etiology
Humans