Progress in Stereoselective Construction of C-C Bonds Enabled by Aldolases and Hydroxynitrile Lyases

Mi Liu; Dan Wei; Zexing Wen; Jian-Bo Wang

doi:10.3389/fbioe.2021.653682

Progress in Stereoselective Construction of C-C Bonds Enabled by Aldolases and Hydroxynitrile Lyases

Front Bioeng Biotechnol. 2021 Apr 21:9:653682. doi: 10.3389/fbioe.2021.653682. eCollection 2021.

Authors

Mi Liu^{1

2}, Dan Wei^{1

2}, Zexing Wen^{1

2}, Jian-Bo Wang^{1

2}

Affiliations

¹ Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, China.
² Key Laboratory of Phytochemistry R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, China.

Abstract

The creation of C-C bonds is an effective strategy for constructing complex compounds from simple synthetic blocks. Although many methods have been developed for C-C bond construction, the stereoselective creation of new C-C bonds remains a challenge. The selectivities (enantioselectivity, regioselectivity, and chemoselectivity) of biocatalysts are higher than those of chemical catalysts, therefore biocatalysts are excellent candidates for use in stereoselective C-C bond formation. Here, we summarize progress made in the past 10 years in stereoselective C-C bond formation enabled by two classic types of enzyme, aldolases and hydroxynitrile lyases. The information in this review will enable the development of new routes to the stereoselective construction of C-C bonds.

Keywords: C-C bond formation; aldolases; biocatalysis; enantioselectivity; hydroxynitrile lyases.

Publication types

Review