1 From the Centre of Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark (CASH), Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital - Ghent University, Ghent, Belgium (SDH) and Department of Anaesthesia and Intensive Care, Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (MSC).