[Supergenes:Generalists in Gene Expression]

Tao Liu; Shu Sen Wang; Lei Yang; Qiao Shi; Zhong Yang Shen

doi:10.3881/j.issn.1000-503X.12419

[Supergenes:Generalists in Gene Expression]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Apr 28;43(2):265-270. doi: 10.3881/j.issn.1000-503X.12419.

[Article in Chinese]

Authors

Tao Liu^{1

2}, Shu Sen Wang^{1

2

3

4}, Lei Yang⁵, Qiao Shi⁶, Zhong Yang Shen^{1

2

3

4}

Affiliations

¹ Key Laboratory of Transplant Medicine,Chinese Academy of Medical Sciences,Tianjin First Central Hospital,Tianjin 300192,China.
² National Health Commission's Key Laboratory of Critical Care Medicine,Tianjin First Central Hospital,Tianjin 300192,China.
³ Tianjin Clinical Research Center of Organ Transplantation,Tianjin First Central Hospital,Tianjin 300192,China.
⁴ Organ Transplantation Center,Tianjin First Central Hospital,Tianjin 300192,China.
⁵ Department of Clinical Laboratory,Tianjin First Central Hospital,Tianjin 300192,China.
⁶ Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China.

PMID: 33966708
DOI: 10.3881/j.issn.1000-503X.12419

Abstract

In eukaryote cells,transcription from genome DNA is a key process of gene expression.The transcription products contain not only messenger RNAs that code proteins,but also various types of non-coding RNAs.During transcription,some of the gene loci produce more than one kind of RNA molecule,including coding RNAs and more often non-coding RNAs.These gene loci that generate several kinds of RNA molecules are named supergenes.According to the transcription pattern,supergenes are divided into three types,known as types Ⅰ,Ⅱ and Ⅲ.In this review,we summarize the transcription pattern of each type of supergene,and exposit the role of these genes in cells.

Keywords: gene regulation; non-coding RNA; supergene; transcription.

Publication types

Review

MeSH terms

Gene Expression
RNA, Messenger*

Substances

RNA, Messenger