Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry

M M Kmiec; D Tse; Periannan Kuppusamy

doi:10.1007/978-3-030-48238-1_41

Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry

Adv Exp Med Biol. 2021:1269:259-263. doi: 10.1007/978-3-030-48238-1_41.

Authors

M M Kmiec¹, D Tse¹, Periannan Kuppusamy²

Affiliations

¹ Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
² Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. kuppu@dartmouth.edu.

PMID: 33966227
DOI: 10.1007/978-3-030-48238-1_41

Abstract

Electron paramagnetic resonance (EPR) oximetry based on lithium naphthalocyanine paramagnetic crystals as oxygen sensors enables direct measurement of the partial pressure of oxygen (pO₂) in tissues. The method uses topical or implantable forms of these oxygen-sensing crystals embedded in a biocompatible siloxane elastomer. This article presents a summary of these sensors for EPR oximetry and their applicability for tissue oxygen measurement in the clinic.

Keywords: Electron paramagnetic resonance (EPR); MicroChip; Oximetry; OxyChip; Partial pressure of oxygen (pO2); SPOTChip.

MeSH terms

Electron Spin Resonance Spectroscopy
Oximetry*
Oxygen*
Partial Pressure
Prostheses and Implants

Substances

Oxygen