Efficacy of dance for Parkinson's disease: a pooled analysis of 372 patients

Sara Mohamed Hasan; Somia Alshafie; Elfatih A Hasabo; Ma'moun Saleh; Walaa Elnaiem; Aya Qasem; Yazan O Alzu'bi; Asmaa Khaled; Mohamed Sayed Zaazouee; Khaled Mohamed Ragab; Anas Zakarya Nourelden; Mohamed Fahmy Doheim

doi:10.1007/s00415-021-10589-4

Efficacy of dance for Parkinson's disease: a pooled analysis of 372 patients

J Neurol. 2022 Mar;269(3):1195-1208. doi: 10.1007/s00415-021-10589-4. Epub 2021 May 8.

Authors

Sara Mohamed Hasan^{1

2}, Somia Alshafie^{3

2}, Elfatih A Hasabo^{4

2}, Ma'moun Saleh^{5

2}, Walaa Elnaiem^{4

2}, Aya Qasem^{6

2}, Yazan O Alzu'bi^{7

2}, Asmaa Khaled^{8

2}, Mohamed Sayed Zaazouee^{1

2}, Khaled Mohamed Ragab^{9

2}, Anas Zakarya Nourelden^{10

2}, Mohamed Fahmy Doheim^{11

12}

Affiliations

¹ Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
² International Medical Research Association (IMedRA), Cairo, Egypt.
³ Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
⁴ Faculty of Medicine, Khartoum University, Khartoum, Sudan.
⁵ Faculty of Medicine, Hashemite University, Az Zarqa', Jordan.
⁶ Medical Analysis, Al-Balqa' Applied University, Al-Zarqa', Jordan.
⁷ Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
⁸ Faculty of Medicine, Tanta University, Tanta, Egypt.
⁹ Faculty of Medicine, Minia University, Minia, Egypt.
¹⁰ Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
¹¹ International Medical Research Association (IMedRA), Cairo, Egypt. fahmydoheim@alumni.harvard.edu.
¹² Faculty of Medicine, Alexandria University, El-Shatby, 22 El-Guish Road, Alexandria, 21526, Egypt. fahmydoheim@alumni.harvard.edu.

PMID: 33966112
DOI: 10.1007/s00415-021-10589-4

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative disorder that presents with motor and nonmotor symptoms such as bradykinesia, resting tremor, postural instability, and cognitive and neuropsychiatric manifestations. Dance therapy or complex motor activity, besides pharmacological treatment, may have benefits in PD patients.

Objective: To assess the effect of dance in patients with PD.

Methods: We searched for clinical trials in PubMed, Scopus, and Web of Science, and Cochrane till April 2020 using relevant keywords. Data were extracted and pooled as mean difference (MD) with 95% confidence interval (CI) by Review Manager 5.3.

Results: Fourteen randomized controlled trials with 372 patients were included. Dance showed a significant improvement over the control group in term of the Unified Parkinson's Disease Rating Scale III (UPDRS III) after three (MD = - 4.49, 95% CI [- 6.78, - 2.21], p = 0.00001), six, (MD = - 5.96, 95% CI [- 8.89, - 3.02], p < 0.0001), and 12 months (MD = - 14.58, 95% CI [- 24.76, - 4.4], p = 0.005), and Mini-BES test after 12 months. Compared to exercise, dance showed a significant improvement in Timed Up and Go (TUG) test, Berg Balance Scale (BBS), and Mini-BES test.

Conclusion: In comparison to other types of exercise or no activity, dance improves the symptoms and outcomes in patients with PD, especially motor symptoms. Dance also has positive effects on balance, functional mobility, and cognition.

Keywords: Dance; Meta-analysis; Parkinson’s disease.

Publication types

Meta-Analysis
Review

MeSH terms

Cognition
Dance Therapy*
Exercise
Humans
Parkinson Disease* / complications
Parkinson Disease* / therapy
Randomized Controlled Trials as Topic